melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD44 surface expression and MMP-2 activity in the conditioned medium were increased to a greater extent in M21/OPN cells as compared with M21 or alpha(v)995 cells.
|
16631740 |
2006 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Endothelin signaling axis activates osteopontin expression through PI3 kinase pathway in A375 melanoma cells.
|
18722093 |
2008 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma osteopontin concentrations in patients with cutaneous melanoma.
|
23934016 |
2013 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of our study was to evaluate the utility of osteoprotegerin (OPG), osteopontin (OPN), epidermal growth factor (EGF) and vascular endothelial growth factor VEGF for the diagnosis and prognosis of melanoma.
|
30061268 |
2018 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of osteopontin has been found in a variety of cancers, including breast cancer, lung cancer, colorectal cancer, stomach cancer, ovarian cancer, and melanoma.
|
17548669 |
2007 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our observations suggest that OPN may be acquired early in melanoma development and progression, and may enhance tumor cell growth in invasive melanoma.
|
15854047 |
2005 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Active FAK in turn accumulated in the nucleus where it led to the expression of osteopontin and other FN-type matrix in both mouse embryonic fibroblasts and human melanoma.
|
28348210 |
2017 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In melanocytes, expression of the secreted adhesion protein OPN was up-regulated by the melanoma-inducing receptor tyrosine kinase Xmrk as well as by the fibroblast growth factor receptor, which plays a decisive role in human melanoma.
|
12183442 |
2002 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The major purpose of this study was to define OPN expression in primary melanomas with differing biological behaviours.
|
25944164 |
2015 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that OPN promotes melanoma cell invasion by activating integrin αvβ3 and down-regulating CD9, a putative metastasis suppressor.
|
24412090 |
2014 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data provide compelling evidence that OPN and COX-2 expressing macrophages are obligatory factors in melanoma growth.
|
23728342 |
2014 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
OPN derived from tumor-activated macrophages modulates the tumor microenvironment and thereby regulate melanoma growth and angiogenesis.
|
24899149 |
2014 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study we report that expression of GLI1 and osteopontin (OPN) increase progressively with the progression of melanoma from primary cutaneous cancer to metastatic melanoma in clinically derived specimens.
|
19556240 |
2009 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Diffuse strong expression of osteopontin was detected in eight samples of uveal melanomas metastatic to the liver.
|
16505010 |
2006 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression data were obtained from 74% of primary melanomas and provided confirmatory evidence that osteopontin expression is a prognostic biomarker.
|
19887478 |
2009 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evaluation of serum osteopontin level and gene polymorphism as biomarkers: analyses from the Nordic Adjuvant Interferon alpha Melanoma trial.
|
25832001 |
2015 |
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
The inverse correlation between OPN and PTEN expression was validated (P<0.02) by immunohistochemistry using melanoma tissue microarrays.
|
16571650 |
2006 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In line with this, immunoblotting showed significantly enhanced baseline and bFGF-induced OPN protein expression in melanoma cell lines which were homozygous for the -443C allele, compared with cell lines with other allelic variants.
|
18459127 |
2009 |
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Elevated levels of the oncoprotein, osteopontin (OPN), are associated with poor outcome of several types of cancers including melanoma.
|
22266849 |
2012 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To optimise predictive models for sentinal node biopsy (SNB) positivity, relapse and survival, using clinico-pathological characteristics and osteopontin gene expression in primary melanomas.
|
20859289 |
2010 |